Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

Molecular chaperones, such as Hsp70, prevent proteotoxicity and maintain homeostasis. This is perhaps most evident in cancer cells, which overexpress Hsp70 and thrive even when harboring high levels of misfolded proteins. To define the response to proteotoxic challenges, we examined adaptive respons...

Descripción completa

Detalles Bibliográficos
Autores principales: Sannino, Sara, Yates, Megan E, Schurdak, Mark E, Oesterreich, Steffi, Lee, Adrian V, Wipf, Peter, Brodsky, Jeffrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275131/
https://www.ncbi.nlm.nih.gov/pubmed/34180400
http://dx.doi.org/10.7554/eLife.64977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275131/
https://www.ncbi.nlm.nih.gov/pubmed/34180400
http://dx.doi.org/10.7554/eLife.64977

Ejemplares similares