Predicting mechanism of action of novel compounds using compound structure and transcriptomic signature coembedding

MOTIVATION: Identifying mechanism of actions (MoA) of novel compounds is crucial in drug discovery. Careful understanding of MoA can avoid potential side effects of drug candidates. Efforts have been made to identify MoA using the transcriptomic signatures induced by compounds. However, these approa...

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Detalles Bibliográficos
Autores principales: Jang, Gwanghoon, Park, Sungjoon, Lee, Sanghoon, Kim, Sunkyu, Park, Sejeong, Kang, Jaewoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Regulatory and Functional Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275331/
https://www.ncbi.nlm.nih.gov/pubmed/34252937
http://dx.doi.org/10.1093/bioinformatics/btab275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275331/
https://www.ncbi.nlm.nih.gov/pubmed/34252937
http://dx.doi.org/10.1093/bioinformatics/btab275

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