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A novel constrained genetic algorithm-based Boolean network inference method from steady-state gene expression data

MOTIVATION: It is a challenging problem in systems biology to infer both the network structure and dynamics of a gene regulatory network from steady-state gene expression data. Some methods based on Boolean or differential equation models have been proposed but they were not efficient in inference o...

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Detalles Bibliográficos
Autores principales: Trinh, Hung-Cuong, Kwon, Yung-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275338/
https://www.ncbi.nlm.nih.gov/pubmed/34252959
http://dx.doi.org/10.1093/bioinformatics/btab295