Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers

PURPOSE: The recent repurposing of ketamine as treatment for pain and depression has increased the need for accurate population pharmacokinetic (PK) models to inform the design of new clinical trials. Therefore, the objectives of this study were to externally validate available PK models on (S)-(nor...

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Detalles Bibliográficos
Autores principales: Otto, M. E., Bergmann, K. R., Jacobs, G., van Esdonk, Michiel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275530/
https://www.ncbi.nlm.nih.gov/pubmed/33575848
http://dx.doi.org/10.1007/s00228-021-03104-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275530/
https://www.ncbi.nlm.nih.gov/pubmed/33575848
http://dx.doi.org/10.1007/s00228-021-03104-1

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