A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases

DNA-Damage Response (DDR) proteins are crucial for maintaining the integrity of the genome by identifying and repairing errors in DNA. Variants affecting their function can have severe consequences since failure to repair damaged DNA can result in cells turning cancerous. Here, we compare germline a...

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Detalles Bibliográficos
Autores principales: Magraner-Pardo, Lorena, Laskowski, Roman A., Pons, Tirso, Thornton, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275599/
https://www.ncbi.nlm.nih.gov/pubmed/34253785
http://dx.doi.org/10.1038/s41598-021-93715-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275599/
https://www.ncbi.nlm.nih.gov/pubmed/34253785
http://dx.doi.org/10.1038/s41598-021-93715-6

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