VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila

The maintenance of constant karyoplasmic ratios suggests that nuclear size has physiological significance. Nuclear size anomalies have been linked to malignant transformation, although the mechanism remains unclear. By expressing dominant-negative TER94 mutants in Drosophila photoreceptors, here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Ya-Chu, Peng, Yu-Xiang, Yu, Bo-Hua, Chang, Henry C., Liang, Pei-Shin, Huang, Ting-Yi, Shih, Chao-Jie, Chu, Li-An, Sang, Tzu-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275807/
https://www.ncbi.nlm.nih.gov/pubmed/34253734
http://dx.doi.org/10.1038/s41467-021-24556-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275807/
https://www.ncbi.nlm.nih.gov/pubmed/34253734
http://dx.doi.org/10.1038/s41467-021-24556-0

Ejemplares similares