Cargando…

VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila

The maintenance of constant karyoplasmic ratios suggests that nuclear size has physiological significance. Nuclear size anomalies have been linked to malignant transformation, although the mechanism remains unclear. By expressing dominant-negative TER94 mutants in Drosophila photoreceptors, here we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Ya-Chu, Peng, Yu-Xiang, Yu, Bo-Hua, Chang, Henry C., Liang, Pei-Shin, Huang, Ting-Yi, Shih, Chao-Jie, Chu, Li-An, Sang, Tzu-Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275807/ https://www.ncbi.nlm.nih.gov/pubmed/34253734 http://dx.doi.org/10.1038/s41467-021-24556-0

Ejemplares similares

ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
por: Lee, Jung-Hee, et al.
Publicado: (2017)

Author Correction: ID3 regulates the MDC1-mediated DNA damage response in order to maintain genome stability
por: Lee, Jung-Hee, et al.
Publicado: (2018)

Karyopherin α-2 Mediates MDC1 Nuclear Import through a Functional Nuclear Localization Signal in the tBRCT Domain of MDC1
por: Radhakrishnan, Kamalakannan, et al.
Publicado: (2020)

Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model
por: Chang, Ya-Chu, et al.
Publicado: (2011)

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
por: Ju, Jeong-Sun, et al.
Publicado: (2009)

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
por: Minter-Dykhouse, Katherine, et al.
Publicado: (2008)

The functional importance of VCP to maintaining cellular protein homeostasis
por: Ahlstedt, Brittany A., et al.
Publicado: (2022)

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis
por: Leimbacher, Pia-Amata, et al.
Publicado: (2019)

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
por: Bekker-Jensen, Simon, et al.
Publicado: (2005)

Recruitment Kinetics of DNA Repair Proteins Mdc1 and Rad52 but Not 53BP1 Depend on Damage Complexity
por: Hable, Volker, et al.
Publicado: (2012)

VCP and ATL1 regulate endoplasmic reticulum and protein synthesis for dendritic spine formation
por: Shih, Yu-Tzu, et al.
Publicado: (2016)

Derlin-1 Regulates Mutant VCP-Linked Pathogenesis and Endoplasmic Reticulum Stress-Induced Apoptosis
por: Liang, Cyong-Jhih, et al.
Publicado: (2014)

The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders
por: Shih, Yu-Tzu, et al.
Publicado: (2018)

The spliceosome-associated protein Mfap1 binds to VCP in Drosophila
por: Rode, Sandra, et al.
Publicado: (2017)

Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci
por: Xu, Jian, et al.
Publicado: (2021)

Valosin Containing Protein (VCP): A Multistep Regulator of Autophagy
por: Ferrari, Veronica, et al.
Publicado: (2022)

MDC-13 Kangaroo mothers in Colombia
por: Charpak, Georges
Publicado: (1999)

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
por: Jungmichel, Stephanie, et al.
Publicado: (2012)

Acetylation of Lysine 382 and Phosphorylation of Serine 392 in p53 Modulate the Interaction between p53 and MDC1 In Vitro
por: Shahar, Or David, et al.
Publicado: (2013)

Inhibition of autophagy, lysosome and VCP function impairs stress granule assembly
por: Seguin, S J, et al.
Publicado: (2014)

Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response
por: Chen, Ting-Yu, et al.
Publicado: (2021)

Cardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function
por: Viswanathan, Meera C., et al.
Publicado: (2016)

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
por: Becherel, Olivier J., et al.
Publicado: (2010)

The Viral Oncoprotein Tax Sequesters DNA Damage Response Factors by Tethering MDC1 to Chromatin
por: Belgnaoui, S. Mehdi, et al.
Publicado: (2010)

CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases
por: Wall, Jordan M., et al.
Publicado: (2021)

Autophagy maintains stem cells and intestinal homeostasis in Drosophila
por: Nagy, Péter, et al.
Publicado: (2018)

Heterozygous mutations in valosin-containing protein (VCP) and resistance to VCP inhibitors
por: Bastola, Prabhakar, et al.
Publicado: (2019)

Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation
por: Huang, Tzyy-Nan, et al.
Publicado: (2020)

Co-selected mutations in VCP: a novel mechanism of resistance to VCP inhibitors
por: Bastola, Prabhakar, et al.
Publicado: (2018)

Phenotype of VCP Mutations in Chinese Amyotrophic Lateral Sclerosis Patients
por: Feng, Shu-Yan, et al.
Publicado: (2022)

Inactivation of VCP/ter94 Suppresses Retinal Pathology Caused by Misfolded Rhodopsin in Drosophila
por: Griciuc, Ana, et al.
Publicado: (2010)

Drosophila VCP/p97 Mediates Dynein-Dependent Retrograde Mitochondrial Motility in Axons
por: Gonzalez, Ashley E., et al.
Publicado: (2020)

Monogenic diabetes clinic (MDC): 3-year experience
por: Rapini, Novella, et al.
Publicado: (2022)

A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer
por: Xue, Yao, et al.
Publicado: (2014)

SVIP Induces Localization of p97/VCP to the Plasma and Lysosomal Membranes and Regulates Autophagy
por: Wang, Yang, et al.
Publicado: (2011)

Primary Human mDC1, mDC2, and pDC Dendritic Cells Are Differentially Infected and Activated by Respiratory Syncytial Virus
por: Johnson, Teresa R., et al.
Publicado: (2011)

Long non-coding RNA MDC1-AS inhibits human gastric cancer cell proliferation and metastasis through an MDC1-dependent mechanism
por: Qin, Ying, et al.
Publicado: (2018)

PINK1 Interacts with VCP/p97 and Activates PKA to Promote NSFL1C/p47 Phosphorylation and Dendritic Arborization in Neurons
por: Wang, Kent Z. Q., et al.
Publicado: (2018)

Nucleolin Participates in DNA Double-Strand Break-Induced Damage Response through MDC1-Dependent Pathway
por: Kobayashi, Junya, et al.
Publicado: (2012)

VCP takes out the trash
por: Short, Ben
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ei1p9bdhn4nrno74kgbne06ktm