PPAR-α Agonist Fenofibrate Prevented Diabetic Nephropathy by Inhibiting M1 Macrophages via Improving Endothelial Cell Function in db/db Mice

Background: Diabetic nephropathy (DN) is one of the major diabetic microvascular complications, and macrophage polarization plays a key role in the development of DN. Endothelial cells regulate macrophage polarization. Peroxisome proliferator-activated receptor (PPAR)-α agonists were demonstrated to...

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Detalles Bibliográficos
Autores principales: Feng, Xiaomeng, Gao, Xia, Wang, Shuo, Huang, Mengxiu, Sun, Zhencheng, Dong, Hengbei, Yu, Haitian, Wang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275839/
https://www.ncbi.nlm.nih.gov/pubmed/34268320
http://dx.doi.org/10.3389/fmed.2021.652558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275839/
https://www.ncbi.nlm.nih.gov/pubmed/34268320
http://dx.doi.org/10.3389/fmed.2021.652558

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