A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes. An in-depth structure–activity relationship–based study has been carried out, and two...

Descripción completa

Detalles Bibliográficos
Autores principales: Tautou, Marie, Eddarkaoui, Sabiha, Descamps, Florian, Larchanché, Paul-Emmanuel, El Bakali, Jamal, Goveas, Liesel Mary, Dumoulin, Mélanie, Lamarre, Chloé, Blum, David, Buée, Luc, Melnyk, Patricia, Sergeant, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276176/
https://www.ncbi.nlm.nih.gov/pubmed/34267657
http://dx.doi.org/10.3389/fphar.2021.679335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276176/
https://www.ncbi.nlm.nih.gov/pubmed/34267657
http://dx.doi.org/10.3389/fphar.2021.679335

Ejemplares similares