Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies

BACKGROUND: Bispecific T cell engagers represent the majority of bispecific antibodies (BsAbs) entering the clinic to treat metastatic cancer. The ability to apply these agents safely and efficaciously in the clinic, particularly for solid tumors, has been challenging. Many preclinical studies have...

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Detalles Bibliográficos
Autores principales: Poussin, Mathilde, Sereno, Arlene, Wu, Xiufeng, Huang, Flora, Manro, Jason, Cao, Shanshan, Carpenito, Carmine, Glasebrook, Andrew, Powell Jr, Daniel J, Demarest, Stephen J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276301/
https://www.ncbi.nlm.nih.gov/pubmed/34253637
http://dx.doi.org/10.1136/jitc-2021-002444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276301/
https://www.ncbi.nlm.nih.gov/pubmed/34253637
http://dx.doi.org/10.1136/jitc-2021-002444

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