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DHX15 is required to control RNA virus-induced intestinal inflammation

RNA helicases play critical roles in various biological processes, including serving as viral RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 (DHX15) is essential for type I interferon (IFN-I, IFN-β), type III IFN (IFN-λ3), and inflammasome-derived cytokine IL-18...

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Detalles Bibliográficos
Autores principales: Xing, Junji, Zhou, Xiaojing, Fang, Mingli, Zhang, Evan, Minze, Laurie J., Zhang, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276442/
https://www.ncbi.nlm.nih.gov/pubmed/34161762
http://dx.doi.org/10.1016/j.celrep.2021.109205