2dFDR: a new approach to confounder adjustment substantially increases detection power in omics association studies

One challenge facing omics association studies is the loss of statistical power when adjusting for confounders and multiple testing. The traditional statistical procedure involves fitting a confounder-adjusted regression model for each omics feature, followed by multiple testing correction. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Sangyoon, Zhang, Xianyang, Yang, Lu, Huang, Jinyan, Liu, Yuanhang, Wang, Chen, Schaid, Daniel J., Chen, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276451/
https://www.ncbi.nlm.nih.gov/pubmed/34256818
http://dx.doi.org/10.1186/s13059-021-02418-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276451/
https://www.ncbi.nlm.nih.gov/pubmed/34256818
http://dx.doi.org/10.1186/s13059-021-02418-8

Ejemplares similares