Electrostatic Interactions Explain the Higher Binding Affinity of the CR3022 Antibody for SARS-CoV-2 than the 4A8 Antibody

[Image: see text] A structural understanding of the mechanism by which antibodies bind SARS-CoV-2 at the atomic level is highly desirable as it can tell the development of more effective antibodies to treat Covid-19. Here, we use steered molecular dynamics (SMD) and coarse-grained simulations to est...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Hung, Lan, Pham Dang, Nissley, Daniel A., O’Brien, Edward P., Li, Mai Suan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276604/
https://www.ncbi.nlm.nih.gov/pubmed/34228472
http://dx.doi.org/10.1021/acs.jpcb.1c03639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276604/
https://www.ncbi.nlm.nih.gov/pubmed/34228472
http://dx.doi.org/10.1021/acs.jpcb.1c03639

Ejemplares similares