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Electrostatic Interactions Explain the Higher Binding Affinity of the CR3022 Antibody for SARS-CoV-2 than the 4A8 Antibody

[Image: see text] A structural understanding of the mechanism by which antibodies bind SARS-CoV-2 at the atomic level is highly desirable as it can tell the development of more effective antibodies to treat Covid-19. Here, we use steered molecular dynamics (SMD) and coarse-grained simulations to est...

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Detalles Bibliográficos
Autores principales:	Nguyen, Hung, Lan, Pham Dang, Nissley, Daniel A., O’Brien, Edward P., Li, Mai Suan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276604/ https://www.ncbi.nlm.nih.gov/pubmed/34228472 http://dx.doi.org/10.1021/acs.jpcb.1c03639

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