In vivo and in vitro human gene essentiality estimations capture contrasting functional constraints

Gene essentiality estimation is a popular empirical approach to link genotypes to phenotypes. In humans, essentiality is estimated based on loss-of-function (LoF) mutation intolerance, either from population exome sequencing (in vivo) data or CRISPR-based in vitro perturbation experiments. Both appr...

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Detalles Bibliográficos
Autores principales: Caldu-Primo, Jose Luis, Verduzco-Martínez, Jorge Armando, Alvarez-Buylla, Elena R, Davila-Velderrain, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Standard Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276763/
https://www.ncbi.nlm.nih.gov/pubmed/34268495
http://dx.doi.org/10.1093/nargab/lqab063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276763/
https://www.ncbi.nlm.nih.gov/pubmed/34268495
http://dx.doi.org/10.1093/nargab/lqab063

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