A fluorescent target-guided Paal–Knorr reaction

It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal–Knorr chemistry applied to the preparation of fluor...

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Detalles Bibliográficos
Autores principales: Wagh, Sachin B., Maslivetc, Vladimir, La Clair, James J., Kornienko, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276889/
https://www.ncbi.nlm.nih.gov/pubmed/34262697
http://dx.doi.org/10.1039/d0ra06962k
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author Wagh, Sachin B.
Maslivetc, Vladimir
La Clair, James J.
Kornienko, Alexander
author_facet Wagh, Sachin B.
Maslivetc, Vladimir
La Clair, James J.
Kornienko, Alexander
author_sort Wagh, Sachin B.
collection PubMed
description It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal–Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).
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spelling pubmed-82768892021-07-13 A fluorescent target-guided Paal–Knorr reaction Wagh, Sachin B. Maslivetc, Vladimir La Clair, James J. Kornienko, Alexander RSC Adv Chemistry It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal–Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2). The Royal Society of Chemistry 2020-10-07 /pmc/articles/PMC8276889/ /pubmed/34262697 http://dx.doi.org/10.1039/d0ra06962k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Wagh, Sachin B.
Maslivetc, Vladimir
La Clair, James J.
Kornienko, Alexander
A fluorescent target-guided Paal–Knorr reaction
title A fluorescent target-guided Paal–Knorr reaction
title_full A fluorescent target-guided Paal–Knorr reaction
title_fullStr A fluorescent target-guided Paal–Knorr reaction
title_full_unstemmed A fluorescent target-guided Paal–Knorr reaction
title_short A fluorescent target-guided Paal–Knorr reaction
title_sort fluorescent target-guided paal–knorr reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276889/
https://www.ncbi.nlm.nih.gov/pubmed/34262697
http://dx.doi.org/10.1039/d0ra06962k
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