Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations

5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimutations to be passed to the next generation. Here, w...

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Detalles Bibliográficos
Autores principales: Karahan, Gurbet, Chan, Donovan, Shirane, Kenjiro, McClatchie, Taylor, Janssen, Sanne, Baltz, Jay M., Lorincz, Matthew, Trasler, Jacquetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276981/
https://www.ncbi.nlm.nih.gov/pubmed/34128976
http://dx.doi.org/10.1242/dev.199492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276981/
https://www.ncbi.nlm.nih.gov/pubmed/34128976
http://dx.doi.org/10.1242/dev.199492

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