LncRNA HBL1 is required for genome-wide PRC2 occupancy and function in cardiogenesis from human pluripotent stem cells

Polycomb repressive complex 2 (PRC2) deposits H3K27me3 on chromatin to silence transcription. PRC2 broadly interacts with RNAs. Currently, the role of the RNA-PRC2 interaction in human cardiogenesis remains elusive. Here, we found that human-specific heart brake lncRNA 1 (HBL1) interacted with two P...

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Detalles Bibliográficos
Autores principales: Liu, Juli, Liu, Sheng, Han, Lei, Sheng, Yi, Zhang, Yucheng, Kim, Il-Man, Wan, Jun, Yang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Human Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276986/
https://www.ncbi.nlm.nih.gov/pubmed/34027990
http://dx.doi.org/10.1242/dev.199628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8276986/
https://www.ncbi.nlm.nih.gov/pubmed/34027990
http://dx.doi.org/10.1242/dev.199628

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