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A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology

The pig is commonly used as an experimental model of human heart disease, including for the study of mechanisms of arrhythmia. However, there exist differences between human and porcine cellular electrophysiology: The pig action potential (AP) has a deeper phase-1 notch, a longer duration at 50% rep...

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Detalles Bibliográficos
Autores principales: Gaur, Namit, Qi, Xiao-Yan, Benoist, David, Bernus, Olivier, Coronel, Ruben, Nattel, Stanley, Vigmond, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277015/
https://www.ncbi.nlm.nih.gov/pubmed/34191797
http://dx.doi.org/10.1371/journal.pcbi.1009137