Learning epistatic gene interactions from perturbation screens

The treatment of complex diseases often relies on combinatorial therapy, a strategy where drugs are used to target multiple genes simultaneously. Promising candidate genes for combinatorial perturbation often constitute epistatic genes, i.e., genes which contribute to a phenotype in a non-linear fas...

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Detalles Bibliográficos
Autores principales: Elmes, Kieran, Schmich, Fabian, Szczurek, Ewa, Jenkins, Jeremy, Beerenwinkel, Niko, Gavryushkin, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277066/
https://www.ncbi.nlm.nih.gov/pubmed/34255784
http://dx.doi.org/10.1371/journal.pone.0254491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277066/
https://www.ncbi.nlm.nih.gov/pubmed/34255784
http://dx.doi.org/10.1371/journal.pone.0254491

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