Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. A rapid overshoot in insulin-stimulated recruitment of Akt to the plasma membrane has previously been reported, which is indicative of negative feedback...

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Detalles Bibliográficos
Autores principales: Kearney, Alison L, Norris, Dougall M, Ghomlaghi, Milad, Kin Lok Wong, Martin, Humphrey, Sean J, Carroll, Luke, Yang, Guang, Cooke, Kristen C, Yang, Pengyi, Geddes, Thomas A, Shin, Sungyoung, Fazakerley, Daniel J, Nguyen, Lan K, James, David E, Burchfield, James G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277355/
https://www.ncbi.nlm.nih.gov/pubmed/34253290
http://dx.doi.org/10.7554/eLife.66942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277355/
https://www.ncbi.nlm.nih.gov/pubmed/34253290
http://dx.doi.org/10.7554/eLife.66942

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