Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans

Misfolded protein oligomers are increasingly recognized as highly cytotoxic agents in a wide range of human disorders associated with protein aggregation. In this study, we assessed the possible uptake and resulting toxic effects of model protein oligomers administered to C. elegans through the cult...

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Detalles Bibliográficos
Autores principales: Perni, Michele, Mannini, Benedetta, Xu, Catherine K., Kumita, Janet R., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277765/
https://www.ncbi.nlm.nih.gov/pubmed/34257326
http://dx.doi.org/10.1038/s41598-021-93527-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277765/
https://www.ncbi.nlm.nih.gov/pubmed/34257326
http://dx.doi.org/10.1038/s41598-021-93527-8

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