Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously suppress viral replication and circumvent viral escape from host immunity and antiviral therapeutics. Here, we employ genome-wide computational p...

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Detalles Bibliográficos
Autores principales: Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277810/
https://www.ncbi.nlm.nih.gov/pubmed/34257311
http://dx.doi.org/10.1038/s41467-021-24577-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277810/
https://www.ncbi.nlm.nih.gov/pubmed/34257311
http://dx.doi.org/10.1038/s41467-021-24577-9

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