Cargando…
Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance
The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously suppress viral replication and circumvent viral escape from host immunity and antiviral therapeutics. Here, we employ genome-wide computational p...
Autores principales: | Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277810/ https://www.ncbi.nlm.nih.gov/pubmed/34257311 http://dx.doi.org/10.1038/s41467-021-24577-9 |
Ejemplares similares
-
De novo design of CRISPR-Cas13b enables efficient silencing of SARS-CoV-2 variants and tumour pathogenic RNAs with near single-base precision
por: Hu, Wenxin, et al.
Publicado: (2022) -
Lionfish misidentification circumvents an optimized escape response by prey
por: McCormick, Mark I., et al.
Publicado: (2016) -
Perforinopathy: A Spectrum of Human Immune Disease Caused by Defective Perforin Delivery or Function
por: Voskoboinik, Ilia, et al.
Publicado: (2013) -
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
por: Thieme, Elana, et al.
Publicado: (2023) -
Circumventing the Greatwall
por: Short, Ben
Publicado: (2014)