Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy

Hypoxia, a characteristic of most human solid tumors, is a major obstacle to successful radiotherapy. While moderate acute hypoxia increases cell survival, chronic cycling hypoxia triggers adaptation processes, leading to the clonal selection of hypoxia-tolerant, apoptosis-resistant cancer cells. Ou...

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Detalles Bibliográficos
Autores principales: Ritter, Violetta, Krautter, Franziska, Klein, Diana, Jendrossek, Verena, Rudner, Justine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277842/
https://www.ncbi.nlm.nih.gov/pubmed/34257274
http://dx.doi.org/10.1038/s41419-021-03971-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277842/
https://www.ncbi.nlm.nih.gov/pubmed/34257274
http://dx.doi.org/10.1038/s41419-021-03971-7

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