Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted

The first exon of the huntingtin protein (HTTex1) important in Huntington’s disease (HD) can form cross-β fibrils of varying toxicity. We find that the difference between these fibrils is the degree of entanglement and dynamics of the C-terminal proline-rich domain (PRD) in a mechanism analogous to...

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Detalles Bibliográficos
Autores principales: Mario Isas, J., Pandey, Nitin K., Xu, Hui, Teranishi, Kazuki, Okada, Alan K., Fultz, Ellisa K., Rawat, Anoop, Applebaum, Anise, Meier, Franziska, Chen, Jeannie, Langen, Ralf, Siemer, Ansgar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277859/
https://www.ncbi.nlm.nih.gov/pubmed/34257293
http://dx.doi.org/10.1038/s41467-021-24411-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277859/
https://www.ncbi.nlm.nih.gov/pubmed/34257293
http://dx.doi.org/10.1038/s41467-021-24411-2

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