Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes. The ensuing BCR-ABL1 chimeric oncogene is characterized by a breakpoint region that generally inv...

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Detalles Bibliográficos
Autores principales: Massimino, Michele, Tirrò, Elena, Stella, Stefania, Manzella, Livia, Pennisi, Maria Stella, Romano, Chiara, Vitale, Silvia Rita, Puma, Adriana, Tomarchio, Cristina, Di Gregorio, Sandra, Antolino, Agostino, Di Raimondo, Francesco, Vigneri, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277938/
https://www.ncbi.nlm.nih.gov/pubmed/34276365
http://dx.doi.org/10.3389/fphar.2021.669469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277938/
https://www.ncbi.nlm.nih.gov/pubmed/34276365
http://dx.doi.org/10.3389/fphar.2021.669469

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