Metformin protects against insulin resistance induced by high uric acid in cardiomyocytes via AMPK signalling pathways in vitro and in vivo

High uric acid (HUA) is associated with insulin resistance (IR) in cardiomyocytes. We investigated whether metformin protects against HUA‐induced IR in cardiomyocytes. We exposed primary cardiomyocytes to HUA, and cellular glucose uptake was quantified by measuring the uptake of 2‐NBDG, a fluorescen...

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Detalles Bibliográficos
Autores principales: Jiao, Zhenyu, Chen, Yingqun, Xie, Yang, Li, Yanbing, Li, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278091/
https://www.ncbi.nlm.nih.gov/pubmed/34053175
http://dx.doi.org/10.1111/jcmm.16677

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278091/
https://www.ncbi.nlm.nih.gov/pubmed/34053175
http://dx.doi.org/10.1111/jcmm.16677

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