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Epigenetic down‐regulation of microRNA‐126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis
Impaired angiogenesis in scleroderma (SSc) is a critical component of SSc pathology. MicroRNA‐126 (miR‐126) is expressed in endothelial cells (MVECs) where it regulates VEGF responses by repressing the negative regulators of VEGF, including the sprouty‐related protein‐1 (SPRED1), and phosphoinositid...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278107/ https://www.ncbi.nlm.nih.gov/pubmed/34137496 http://dx.doi.org/10.1111/jcmm.16727 |