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Epigenetic down‐regulation of microRNA‐126 in scleroderma endothelial cells is associated with impaired responses to VEGF and defective angiogenesis

Impaired angiogenesis in scleroderma (SSc) is a critical component of SSc pathology. MicroRNA‐126 (miR‐126) is expressed in endothelial cells (MVECs) where it regulates VEGF responses by repressing the negative regulators of VEGF, including the sprouty‐related protein‐1 (SPRED1), and phosphoinositid...

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Detalles Bibliográficos
Autores principales:	Wang, Yongqing, Sun, John, Kahaleh, Bashar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278107/ https://www.ncbi.nlm.nih.gov/pubmed/34137496 http://dx.doi.org/10.1111/jcmm.16727

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