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Differential Proximity of Perisynaptic Astrocytic Best1 at the Excitatory and Inhibitory Tripartite Synapses in APP/PS1 and MAOB-KO Mice Revealed by Lattice Structured Illumination Microscopy

Bestrophin-1 (Best1) is a GABA- and glutamate-permeable, Ca(2+)-activated Cl(-) channel, which is mainly expressed in astrocytes and localized at the microdomain or perisynaptic junction of the tripartite synapse. Distribution of Best1 is dramatically changed in pathological conditions such as Alzhe...

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Detalles Bibliográficos
Autores principales: An, Heeyoung, Koh, Wuhyun, Kang, SeungHee, Nam, Min-Ho, Lee, C. Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Brain and Neural Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278139/
https://www.ncbi.nlm.nih.gov/pubmed/34132201
http://dx.doi.org/10.5607/en21015