Cargando…

Downregulation of tumor‐derived exosomal miR-34c induces cancer‐associated fibroblast activation to promote cholangiocarcinoma progress

BACKGROUND: This study aimed to investigate the exact regulatory mechanisms of exosomal miR-34c in mediating communication between cholangiocarcinoma cells and fibroblasts. METHODS: Exosomes were isolated from HuCCT-1 and HIBEC cells using differential ultracentrifugation and identified by transmiss...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Xinglei, Lu, Min, Li, Gang, Zhou, Yajun, Liu, Zhaoyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278610/ https://www.ncbi.nlm.nih.gov/pubmed/34261453 http://dx.doi.org/10.1186/s12935-020-01726-6

Ejemplares similares

MiR-34a and miR-206 act as novel prognostic and therapy biomarkers in cervical cancer
por: Chen, Ai-Hua, et al.
Publicado: (2017)

Linc00473 potentiates cholangiocarcinoma progression by modulation of DDX5 expression via miR-506 regulation
por: Huang, Lining, et al.
Publicado: (2020)

Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis
por: Lu, Min, et al.
Publicado: (2021)

Macrophages-derived exosomal lncRNA LIFR-AS1 promotes osteosarcoma cell progression via miR-29a/NFIA axis
por: Zhang, Hongliang, et al.
Publicado: (2021)

Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression
por: Guo, Dengfang, et al.
Publicado: (2022)

miR-34a mimic or pre-mir-34a, which is the better option for cancer therapy? KatoIII as a model to study miRNA action in human gastric cancer cells
por: Jafari, Narjes, et al.
Publicado: (2021)

miR-223-3p carried by cancer-associated fibroblast microvesicles targets SORBS1 to modulate the progression of gastric cancer
por: Jin, Xiaoli, et al.
Publicado: (2022)

LINC02418 promotes colon cancer progression by suppressing apoptosis via interaction with miR-34b-5p/BCL2 axis
por: Tian, Jun, et al.
Publicado: (2020)

Downregulation of hypermethylated in cancer-1 by miR-4532 promotes adriamycin resistance in breast cancer cells
por: Feng, Fan, et al.
Publicado: (2018)

miR-429 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by downregulation of TLN1
por: Wang, Zhihui, et al.
Publicado: (2019)

MiR-26a/miR-26b represses tongue squamous cell carcinoma progression by targeting PAK1
por: Wei, Zhenxing, et al.
Publicado: (2020)

Associations between microRNA (miR-25, miR-32, miR-125, and miR-222) polymorphisms and recurrent implantation failure in Korean women
por: Lee, Jeong Yong, et al.
Publicado: (2019)

Cervical cancer-derived exosomal miR-663b promotes angiogenesis by inhibiting vinculin expression in vascular endothelial cells
por: You, Xuewu, et al.
Publicado: (2021)

MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway
por: Wang, Da, et al.
Publicado: (2021)

Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression
por: Wang, Xiaoning, et al.
Publicado: (2019)

CircRFX3 contributes to glioma progression through the circRFX3-miR-1179/miR-1229-VASP axis
por: Li, Hongli, et al.
Publicado: (2021)

Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway
por: Li, Qianping, et al.
Publicado: (2019)

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression
por: Liu, Junqiang, et al.
Publicado: (2022)

Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16
por: Liu, Wanshun, et al.
Publicado: (2021)

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients
por: Cha, Diana J., et al.
Publicado: (2019)

LncRNA TP73‐AS1 promotes nasopharyngeal carcinoma progression through targeting miR-342-3p and M2 polarization via exosomes
por: Yao, Hongchao, et al.
Publicado: (2022)

Exosomal miR-126 blocks the development of non-small cell lung cancer through the inhibition of ITGA6
por: Li, Mingjun, et al.
Publicado: (2020)

The plasma exosomal miR-1180-3p serves as a novel potential diagnostic marker for cutaneous melanoma
por: Guo, Yeye, et al.
Publicado: (2021)

Downregulation of circular RNA hsa_circ_0000735 boosts prostate cancer sensitivity to docetaxel via sponging miR-7
por: Gao, Yisheng, et al.
Publicado: (2020)

miR-363 suppresses the proliferation, migration and invasion of clear cell renal cell carcinoma by downregulating S1PR1
por: Xie, Yongpeng, et al.
Publicado: (2020)

Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia
por: Xie, Kairu, et al.
Publicado: (2021)

MiR-4310 induced by SP1 targets PTEN to promote glioma progression
por: Wu, Zhiyong, et al.
Publicado: (2020)

miR-198 inhibits the progression of renal cell carcinoma by targeting BIRC5
por: Yuan, Chao, et al.
Publicado: (2021)

Engineered exosomes loaded with miR-449a selectively inhibit the growth of homologous non-small cell lung cancer
por: Zhou, Wen, et al.
Publicado: (2021)

Exosome-transmitted miR-3124-5p promotes cholangiocarcinoma development via targeting GDF11
por: Gao, Huijie, et al.
Publicado: (2022)

CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression
por: Liu, Yi, et al.
Publicado: (2021)

Long non-coding RNA CASC2 upregulates PTEN to suppress pancreatic carcinoma cell metastasis by downregulating miR-21
por: Zhang, Hui, et al.
Publicado: (2019)

LncRNA MEG8 promotes NSCLC progression by modulating the miR-15a-5p-miR-15b-5p/PSAT1 axis
por: Guo, Kai, et al.
Publicado: (2021)

Exosomes from tamoxifen-resistant breast cancer cells transmit drug resistance partly by delivering miR-9-5p
por: Liu, Jianhui, et al.
Publicado: (2021)

Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p
por: Gao, Ying, et al.
Publicado: (2022)

Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis
por: Zhang, Li, et al.
Publicado: (2020)

miR-335-5p suppresses gastric cancer progression by targeting MAPK10
por: Gao, Yi, et al.
Publicado: (2021)

MAFG-AS1 aggravates the progression of pancreatic cancer by sponging miR-3196 to boost NFIX
por: Ye, Liqing, et al.
Publicado: (2020)

LncRNA ANRIL/miR-7-5p/TCF4 axis contributes to the progression of T cell acute lymphoblastic leukemia
por: Li, Gang, et al.
Publicado: (2020)

Exosomal LINC00460/miR-503-5p/ANLN positive feedback loop aggravates pancreatic cancer progression through regulating T cell–mediated cytotoxicity and PD-1 checkpoint
por: Yao, Jun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4lj258pedijseq06k97umv1g94