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Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation

INTRODUCTION: Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (SST+ GABA cells) are commonly reported in human studies of mood and anxiety disorder patients. A causal link between SST+ cell dysfunction and symptom-related behaviors has been proposed based on rodent studies sho...

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Detalles Bibliográficos
Autores principales: Fee, Corey, Prevot, Thomas D, Misquitta, Keith, Knutson, Daniel E, Li, Guanguan, Mondal, Prithu, Cook, James M, Banasr, Mounira, Sibille, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278801/
https://www.ncbi.nlm.nih.gov/pubmed/33438026
http://dx.doi.org/10.1093/ijnp/pyab002