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Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood–brain barrier using focused ultrasound

One of the key hallmarks of Alzheimer's disease is the aggregation of the amyloid-β peptide to form fibrils. Consequently, there has been great interest in studying molecules that can disrupt amyloid-β aggregation. While a handful of molecules have been shown to inhibit amyloid-β aggregation in...

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Detalles Bibliográficos
Autores principales: Chan, Tiffany G., Ruehl, Carmen L., Morse, Sophie V., Simon, Michelle, Rakers, Viktoria, Watts, Helena, Aprile, Francesco A., Choi, James J., Vilar, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278877/
https://www.ncbi.nlm.nih.gov/pubmed/34349923
http://dx.doi.org/10.1039/d1sc02273c