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Short, enantioselective, gram-scale synthesis of (−)-zephyranthine

A reasonable synthesis design by strategically integrating functional group manipulation into the ring system construction resulted in a short, enantioselective, gram-scale total synthesis of (−)-zephyranthine. The concise route includes a catalytic Michael/Michael cascade for the asymmetric synthes...

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Detalles Bibliográficos
Autores principales: Zhao, Yuxiang, Zhu, Yanren, Ma, Guolan, Wei, Qi, Yang, Shaoxiong, Zeng, Xiaoyu, Zhang, Hongbin, Chen, Jingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278928/
https://www.ncbi.nlm.nih.gov/pubmed/34349919
http://dx.doi.org/10.1039/d1sc03147c