Scalable synthesis and coupling of quaternary α-arylated amino acids: α-aryl substituents are tolerated in α-helical peptides

Quaternary amino acids are important tools for the modification and stabilisation of peptide secondary structures. Here we describe a practical and scalable synthesis applicable to quaternary alpha-arylated amino acids (Q4As), and the development of solid-phase synthesis conditions for their incorpo...

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Detalles Bibliográficos
Autores principales: Leonard, Daniel J., Zieleniewski, Francis, Wellhöfer, Isabelle, Baker, Emily G., Ward, John W., Woolfson, Derek N., Clayden, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278958/
https://www.ncbi.nlm.nih.gov/pubmed/34349911
http://dx.doi.org/10.1039/d1sc01378e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278958/
https://www.ncbi.nlm.nih.gov/pubmed/34349911
http://dx.doi.org/10.1039/d1sc01378e

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