Synthesis, Optimization, and Biological Evaluation of Corrinated Conjugates of the GLP-1R Agonist Exendin-4

[Image: see text] Corrination is the conjugation of a corrin ring containing molecule, such as vitamin B(12) (B12) or B12 biosynthetic precursor dicyanocobinamide (Cbi), to small molecules, peptides, or proteins with the goal of modifying pharmacology. Recently, a corrinated GLP-1R agonist (GLP-1RA)...

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Detalles Bibliográficos
Autores principales: Tinsley, Ian C., Borner, Tito, Swanson, MacKenzie L., Chepurny, Oleg G., Doebley, Sarah A., Kamat, Varun, Sweet, Ian R., Holz, George G., Hayes, Matthew R., De Jonghe, Bart C., Doyle, Robert P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279408/
https://www.ncbi.nlm.nih.gov/pubmed/33677970
http://dx.doi.org/10.1021/acs.jmedchem.1c00185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279408/
https://www.ncbi.nlm.nih.gov/pubmed/33677970
http://dx.doi.org/10.1021/acs.jmedchem.1c00185

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