Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins

[Image: see text] The A-type Aurora kinase is upregulated in many human cancers, and it stabilizes MYC-family oncoproteins, which have long been considered an undruggable target. Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase ac...

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Detalles Bibliográficos
Autores principales: Chi, Ya-Hui, Yeh, Teng-Kuang, Ke, Yi-Yu, Lin, Wen-Hsing, Tsai, Chia-Hua, Wang, Wan-Ping, Chen, Yen-Ting, Su, Yu-Chieh, Wang, Pei-Chen, Chen, Yan-Fu, Wu, Zhong-Wei, Yeh, Jen-Yu, Hung, Ming-Chun, Wu, Mine-Hsine, Wang, Jing-Ya, Chen, Ching-Ping, Song, Jen-Shin, Shih, Chuan, Chen, Chiung-Tong, Chang, Chun-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279414/
https://www.ncbi.nlm.nih.gov/pubmed/34009981
http://dx.doi.org/10.1021/acs.jmedchem.0c01806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279414/
https://www.ncbi.nlm.nih.gov/pubmed/34009981
http://dx.doi.org/10.1021/acs.jmedchem.0c01806

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