Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety

[Image: see text] The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor...

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Detalles Bibliográficos
Autores principales: Sainas, Stefano, Giorgis, Marta, Circosta, Paola, Gaidano, Valentina, Bonanni, Davide, Pippione, Agnese C., Bagnati, Renzo, Passoni, Alice, Qiu, Yaqi, Cojocaru, Carina Florina, Canepa, Barbara, Bona, Alessandro, Rolando, Barbara, Mishina, Mariia, Ramondetti, Cristina, Buccinnà, Barbara, Piccinini, Marco, Houshmand, Mohammad, Cignetti, Alessandro, Giraudo, Enrico, Al-Karadaghi, Salam, Boschi, Donatella, Saglio, Giuseppe, Lolli, Marco L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279415/
https://www.ncbi.nlm.nih.gov/pubmed/33844533
http://dx.doi.org/10.1021/acs.jmedchem.0c01549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279415/
https://www.ncbi.nlm.nih.gov/pubmed/33844533
http://dx.doi.org/10.1021/acs.jmedchem.0c01549

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