Heterodimeric GW7604 Derivatives: Modification of the Pharmacological Profile by Additional Interactions at the Coactivator Binding Site

[Image: see text] (E/Z)-3-(4-((E)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)phenyl)acrylic acid (GW7604) as a derivative of (Z)-4-hydroxytamoxifen (4-OHT) was linked by diaminoalkane spacers to molecules that are known binders to the coactivator binding site (benzimidazole or thioxo-quinazolinone scaff...

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Detalles Bibliográficos
Autores principales: Knox, Alexandra K., Kalchschmid, Christina, Schuster, Daniela, Gaggia, Francesca, Gust, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279417/
https://www.ncbi.nlm.nih.gov/pubmed/33904307
http://dx.doi.org/10.1021/acs.jmedchem.0c02230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279417/
https://www.ncbi.nlm.nih.gov/pubmed/33904307
http://dx.doi.org/10.1021/acs.jmedchem.0c02230

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