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Synthesis of 4-O-Alkylated N-Acetylneuraminic Acid Derivatives

[Image: see text] The synthesis of 4-O-alkyl analogues of N-acetylneuraminic acid (Neu5Ac) and the scope of the reaction are described. Activated alkyl halides and sulfonates and primary alkyl iodides give products in useful yields. The utility of the methodology is exemplified using a thiophenyl Ne...

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Detalles Bibliográficos
Autores principales: Johansson, Emil, Caraballo, Rémi, Elofsson, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279483/
https://www.ncbi.nlm.nih.gov/pubmed/34138565
http://dx.doi.org/10.1021/acs.joc.1c00235