Extracellular GAPDH Promotes Alzheimer Disease Progression by Enhancing Amyloid-β Aggregation and Cytotoxicity

Neuronal cell death at late stages of Alzheimer’s disease (AD) causes the release of cytosolic proteins. One of the most abundant such proteins, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), forms stable aggregates with extracellular amyloid-β (Aβ). We detect these aggregates in cerebrospinal fl...

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Detalles Bibliográficos
Autores principales: Lazarev, Vladimir F, Tsolaki, Magda, Mikhaylova, Elena R, Benken, Konstantin A, Shevtsov, Maxim A, Nikotina, Alina D, Lechpammer, Mirna, Mitkevich, Vladimir A, Makarov, Alexander A, Moskalev, Alexey A, Kozin, Sergey A, Margulis, Boris A, Guzhova, Irina V, Nudler, Evgeny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2021
Materias:
Orginal Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279520/
https://www.ncbi.nlm.nih.gov/pubmed/34341704
http://dx.doi.org/10.14336/AD.2020.1230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279520/
https://www.ncbi.nlm.nih.gov/pubmed/34341704
http://dx.doi.org/10.14336/AD.2020.1230

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