Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA double-strand breaks. Through the use of an unbiased ge...

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Detalles Bibliográficos
Autores principales: Bossaert, Madeleine, Pipier, Angélique, Riou, Jean-Francois, Noirot, Céline, Nguyên, Linh-Trang, Serre, Remy-Felix, Bouchez, Olivier, Defrancq, Eric, Calsou, Patrick, Britton, Sébastien, Gomez, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279764/
https://www.ncbi.nlm.nih.gov/pubmed/34180392
http://dx.doi.org/10.7554/eLife.65184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8279764/
https://www.ncbi.nlm.nih.gov/pubmed/34180392
http://dx.doi.org/10.7554/eLife.65184

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