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A novel methylated analogue of L-Mimosine exerts its therapeutic potency through ROS production and ceramide-induced apoptosis in malignant melanoma

Melanoma is an aggressive and highly metastatic type of skin cancer where the design of new therapies is of utmost importance for the clinical management of the disease. Thus, we have aimed to investigate the mode of action by which a novel methylated analogue of L-Mimosine (e.g., L-SK-4) exerts its...

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Detalles Bibliográficos
Autores principales: Kyriakou, Sotiris, Cheung, William, Mantso, Theodora, Mitsiogianni, Melina, Anestopoulos, Ioannis, Veuger, Stephany, Trafalis, Dimitris T., Franco, Rodrigo, Pappa, Aglaia, Tetard, David, Panayiotidis, Mihalis I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280034/
https://www.ncbi.nlm.nih.gov/pubmed/33624234
http://dx.doi.org/10.1007/s10637-021-01087-5