The long noncoding RNA HOTAIRM1 controlled by AML1 enhances glucocorticoid resistance by activating RHOA/ROCK1 pathway through suppressing ARHGAP18

Acquired resistance to glucocorticoids (GCs) is an obstacle to the effective treatment of leukemia, but the molecular mechanisms of steroid insensitivity have not been fully elucidated. In this study, we established an acquired GC-resistant leukemia cell model and found a long noncoding RNA, HOTAIRM...

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Detalles Bibliográficos
Autores principales: Liang, Liang, Gu, Wenbin, Li, Meng, Gao, Ran, Zhang, Xin, Guo, Chongye, Mi, Shuangli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280127/
https://www.ncbi.nlm.nih.gov/pubmed/34262023
http://dx.doi.org/10.1038/s41419-021-03982-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280127/
https://www.ncbi.nlm.nih.gov/pubmed/34262023
http://dx.doi.org/10.1038/s41419-021-03982-4

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