A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies

Intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders, collectively termed as tauopathies, including the most common Alzheimer’s disease (AD). Therefore, selectively removing or reducing hyperphosphorylated tau is promising for...

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Detalles Bibliográficos
Autores principales: Zheng, Jie, Tian, Na, Liu, Fei, Zhang, Yidian, Su, Jingfen, Gao, Yang, Deng, Mingmin, Wei, Linyu, Ye, Jingwang, Li, Honglian, Wang, Jian-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280143/
https://www.ncbi.nlm.nih.gov/pubmed/34262014
http://dx.doi.org/10.1038/s41392-021-00669-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280143/
https://www.ncbi.nlm.nih.gov/pubmed/34262014
http://dx.doi.org/10.1038/s41392-021-00669-2

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