A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes together. Securin must be depleted before anaphase to ensure chromosome segregation occurs with anaphase. Here we find that...

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Detalles Bibliográficos
Autores principales: Thomas, Christopher, Wetherall, Benjamin, Levasseur, Mark D., Harris, Rebecca J., Kerridge, Scott T., Higgins, Jonathan M. G., Davies, Owen R., Madgwick, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280194/
https://www.ncbi.nlm.nih.gov/pubmed/34262048
http://dx.doi.org/10.1038/s41467-021-24554-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280194/
https://www.ncbi.nlm.nih.gov/pubmed/34262048
http://dx.doi.org/10.1038/s41467-021-24554-2

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