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A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes
Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes together. Securin must be depleted before anaphase to ensure chromosome segregation occurs with anaphase. Here we find that...
Autores principales: | Thomas, Christopher, Wetherall, Benjamin, Levasseur, Mark D., Harris, Rebecca J., Kerridge, Scott T., Higgins, Jonathan M. G., Davies, Owen R., Madgwick, Suzanne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280194/ https://www.ncbi.nlm.nih.gov/pubmed/34262048 http://dx.doi.org/10.1038/s41467-021-24554-2 |
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