Smoking accelerates renal cystic disease and worsens cardiac phenotype in Pkd1-deficient mice

Smoking has been associated with renal disease progression in ADPKD but the underlying deleterious mechanisms and whether it specifically worsens the cardiac phenotype remain unknown. To investigate these matters, Pkd1-deficient cystic mice and noncystic littermates were exposed to smoking from conc...

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Detalles Bibliográficos
Autores principales: Sousa, Marciana V., Amaral, Andressa G., Freitas, Jessica A., Murata, Gilson M., Watanabe, Elieser H., Balbo, Bruno E., Tavares, Marcelo D., Hortegal, Renato A., Rocon, Camila, Souza, Leandro E., Irigoyen, Maria C., Salemi, Vera M., Onuchic, Luiz F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280209/
https://www.ncbi.nlm.nih.gov/pubmed/34262092
http://dx.doi.org/10.1038/s41598-021-93633-7

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