MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

MYCN is an oncogenic driver in neural crest-derived neuroblastoma and medulloblastoma. To better understand the early effects of MYCN activation in a neural-crest lineage context, we profiled the transcriptome of immortalized human retina pigment epithelial cells with inducible MYCN activation. Gene...

Descripción completa

Detalles Bibliográficos
Autores principales: Zanotti, Sofia, Vanhauwaert, Suzanne, Van Neste, Christophe, Olexiouk, Volodimir, Van Laere, Jolien, Verschuuren, Marlies, Van der Meulen, Joni, Mus, Liselot M., Durinck, Kaat, Tilleman, Laurentijn, Deforce, Dieter, Van Nieuwerburgh, Filip, Hogarty, Michael D., Decaesteker, Bieke, De Vos, Winnok H., Speleman, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280219/
https://www.ncbi.nlm.nih.gov/pubmed/34262099
http://dx.doi.org/10.1038/s41598-021-93863-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280219/
https://www.ncbi.nlm.nih.gov/pubmed/34262099
http://dx.doi.org/10.1038/s41598-021-93863-9

Ejemplares similares